Schmidt E B, Kristensen S D, De Caterina R, Illingworth D R
Division of Endocrinology, Department of Medicine, Oregon Health Sciences University, Portland.
Atherosclerosis. 1993 Nov;103(2):107-21. doi: 10.1016/0021-9150(93)90254-r.
This review discusses the effects of dietary n-3 fatty acids on the plasma concentrations and metabolism of lipoproteins with a particular focus on work in human subjects. The influence of dietary n-3 fatty acids on the concentrations of plasma lipoproteins are affected by the amount of n-3 fatty acids as well as by the lipoprotein phenotype in the patients under investigation. On the basis of the observed changes in lipoproteins, dietary n-3 fatty acids exert the greatest effects on the concentrations of triglyceride-rich lipoproteins; their therapeutic potential is greatest in patients with hypertriglyceridemia. In addition to their effects on plasma lipoproteins, dietary n-3 fatty acids have been reported to exert potentially favorable effects on blood pressure, platelet function and viscosity. These effects may justify the use of supplements of dietary n-3 fatty acids in selected patients with hypertriglyceridemia to reduce the risk of atherosclerosis; however, the benefits of such therapy remain to be demonstrated.
本综述讨论了膳食n-3脂肪酸对脂蛋白血浆浓度和代谢的影响，特别关注在人体受试者中的研究。膳食n-3脂肪酸对血浆脂蛋白浓度的影响受n-3脂肪酸的量以及所研究患者的脂蛋白表型影响。基于观察到的脂蛋白变化，膳食n-3脂肪酸对富含甘油三酯的脂蛋白浓度影响最大；其治疗潜力在高甘油三酯血症患者中最大。除了对血浆脂蛋白的影响外，据报道膳食n-3脂肪酸对血压、血小板功能和粘度有潜在的有利影响。这些影响可能证明在选定的高甘油三酯血症患者中使用膳食n-3脂肪酸补充剂以降低动脉粥样硬化风险是合理的；然而，这种治疗的益处仍有待证实。
