健康受试者ω-3指数的改善不会改变膳食饱和脂肪或n-6多不饱和脂肪酸对低密度脂蛋白谱的影响。

Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles.

作者信息

Dias Cintia B, Amigó Núria, Wood Lisa G, Mallol Roger, Correig Xavier, Garg Manohar L

机构信息

Nutraceuticals Research Group, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia.

Metabolomics Platform, Rovira i Virgili University, IISPV, Avinguda Països Catalans 26, 43007 Tarragona, Spain; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), C/ Monforte de Lemos 3-5, 28029, Madrid, Spain; Biosfer Teslab, Plaça Prim 10, 2on 5a, 43201 Reus, Spain.

出版信息

Metabolism. 2017 Mar;68:11-19. doi: 10.1016/j.metabol.2016.11.014. Epub 2016 Dec 1.

DOI:10.1016/j.metabol.2016.11.014

PMID:28183443

Abstract

BACKGROUND AND AIMS

Dietary fat composition is known to modulate circulating lipid and lipoprotein levels. Although supplementation with long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to reduce plasma triglyceride levels, the effect of the interactions between LCn-3PUFA and the major dietary fats consumed has not been previously investigated.

METHODS

In a randomized controlled parallel design clinical intervention, we examined the effect of diets rich in either saturated fatty acids (SFA) or omega-6 polyunsaturated fatty acids (n-6PUFA) on plasma lipid levels and lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) in subjects with an adequate omega 3 index. Twenty six healthy subjects went through a four-week pre-supplementation period with LCn-3PUFA and were then randomized to diets rich in either n-6PUFA or SFA both supplemented with LCn-3PUFA.

RESULTS

The diet rich in n-6PUFA decreased low density lipoprotein (LDL) particle concentration (-8%, p=0.013) and LDL cholesterol (LDL-C) level (-8%, p=0.021), while the saturated fat rich diet did not affect LDL particle concentration or LDL-C levels significantly. Nevertheless, dietary saturated fatty acids increased LCn-3PUFA in plasma and tissue lipids compared with n-6PUFA, potentially reducing other cardiovascular risk factors such as inflammation and clotting tendency.

CONCLUSION

Improvement on the omega 3 index of healthy subjects did not alter the known effects of dietary saturated fats and n-6PUFA on LDL profiles.

摘要

背景与目的

已知膳食脂肪组成可调节循环脂质和脂蛋白水平。尽管补充长链ω-3多不饱和脂肪酸（LCn-3PUFA）已被证明可降低血浆甘油三酯水平，但此前尚未研究LCn-3PUFA与所摄入的主要膳食脂肪之间相互作用的影响。

方法

在一项随机对照平行设计的临床干预中，我们研究了富含饱和脂肪酸（SFA）或ω-6多不饱和脂肪酸（n-6PUFA）的饮食对ω-3指数充足的受试者血浆脂质水平和脂蛋白谱（脂蛋白大小、浓度及亚类分布）的影响。26名健康受试者在补充LCn-3PUFA的情况下经历了为期四周的预补充期，然后被随机分配到富含n-6PUFA或SFA且均补充了LCn-3PUFA的饮食组。

结果

富含n-6PUFA的饮食降低了低密度脂蛋白（LDL）颗粒浓度（-8%，p=0.013）和LDL胆固醇（LDL-C）水平（-8%，p=0.021），而富含饱和脂肪的饮食对LDL颗粒浓度或LDL-C水平无显著影响。然而，与n-6PUFA相比，膳食饱和脂肪酸增加了血浆和组织脂质中的LCn-3PUFA，可能降低了其他心血管危险因素，如炎症和凝血倾向。