Senay E C, Barthwell A G, Marks R, Bokos P, Gillman D, White R
Illinois Department of Alcoholism and Substance, University of Chicago.
J Addict Dis. 1993;12(4):59-76. doi: 10.1300/J069v12n04_05.
In a one year study, 130 methadone maintained subjects with a six month history of good treatment performance were assigned randomly to an experimental condition of one monthly non-random urine screen, one monthly counseling session, one monthly doctor visit, two times per month methadone pick up, a quarterly true random urine screen and participation in a diversion control program or to a control condition of staying under standard conditions for six months and then being transferred to the experimental condition for six months. Results of urine screens and scores on the Addiction Severity Index (ASI) at entrance and six month intervals showed no differences between groups. Three out of four subjects completed the year in good standing. Subject satisfaction was such that the IRB judged that return to standard conditions would be a hardship. Experimental conditions were cheaper such that resources freed up could be applied to the HIV epidemic.
在一项为期一年的研究中,130名美沙酮维持治疗对象,他们有六个月良好治疗表现的病史,被随机分配到一种实验条件下,即每月进行一次非随机尿液筛查、每月一次咨询会议、每月一次医生问诊、每月两次美沙酮领取、每季度进行一次真正的随机尿液筛查并参与转移控制项目;或者被分配到一种对照条件下,即先在标准条件下维持六个月,然后再转入实验条件下六个月。入组时以及每隔六个月的尿液筛查结果和成瘾严重程度指数(ASI)评分显示,两组之间没有差异。四分之三的受试者顺利完成了一年的研究。受试者满意度很高,以至于机构审查委员会(IRB)判定恢复到标准条件会很困难。实验条件成本更低,因此节省下来的资源可用于应对艾滋病毒疫情。