Adler G, Gattaz W F
Unit Neurobiology of Functional Psychoses, Central Institute of Mental Health, Mannheim, Germany.
Biol Psychiatry. 1993 Nov 15;34(10):687-9. doi: 10.1016/0006-3223(93)90041-b.
Somatosensory perception threshold (SPT) and pain perception threshold (PPT) were studied in 16 patients with major depression, compared to the findings in an age-matched and gender-matched control group and related to the psychopathological state evaluated by means of the Hamilton Depression Scale. Perception thresholds were assessed by means of a noninvasive high-frequency electric skin stimulation. Absolute perception thresholds were increased in the patients. However, the relative pain perception threshold (RPPT = PPT: SPT) was significantly reduced. RPPT was positively correlated with retardation. It was negatively correlated with anxiety, suggesting that a reduction of pain perception thresholds in depressive patients may be attributed to anxiety and impaired stress-coping.
对16例重度抑郁症患者的体感知觉阈值（SPT）和疼痛知觉阈值（PPT）进行了研究，并与年龄和性别匹配的对照组的研究结果进行比较，且这些阈值与通过汉密尔顿抑郁量表评估的心理病理状态相关。通过无创高频皮肤电刺激来评估知觉阈值。患者的绝对知觉阈值升高。然而，相对疼痛知觉阈值（RPPT = PPT: SPT）显著降低。RPPT与迟缓呈正相关。它与焦虑呈负相关，这表明抑郁症患者疼痛知觉阈值的降低可能归因于焦虑和应激应对受损。
