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[刚果疟疾高度流行区儿童中恶性疟原虫、三日疟原虫和卵形疟原虫的寄生虫学发病率及恢复率估计]

[Estimation of the parasitological incidence and recovery rates of Plasmodium falciparum, P. malariae and P. ovale among children living in a malarial holoendemic zone in Congo].

作者信息

Trape J F

机构信息

ORSTOM, Laboratoire de Paludologie, Dakar, Sénégal.

出版信息

Bull Soc Pathol Exot. 1993;86(4):248-53.

PMID:8292913
Abstract

The incidence and recovery rates of P. falciparum, P. malariae and P. ovale parasitaemia among schoolchildren from a Congolese village where malaria transmission is intense and perennial were studied from longitudinal data. Time intervals between sampling were two days, eight days, two weeks, two months and four months for the different surveys. Values derived from the model of BEKESSY et al. (1976) showed a great range of variation for P. falciparum (daily incidence rate h: 0.0119-0.0529; daily recovery rate r: 0.0043-0.0198) and for P. malariae (h: 0.0053-0.0103; r: 0.0115-0.0428). For P. ovale this model only fitted samples collected with a maximum time interval of eight days (h: 0.0048-0.0058; r: 0.1400-0.1540). Although discrepancies between estimates may be explained in part by differences in malaria transmission, the results indicate that only short time intervals of sampling gave correct estimates of incidence and recovery rates in the population studied. The importance of this parameter has probably been insufficiently considered until now.

摘要

利用纵向数据,对来自刚果一个疟疾传播强烈且常年流行的村庄的学童中恶性疟原虫、三日疟原虫和卵形疟原虫血症的发病率及恢复率进行了研究。不同调查的采样时间间隔分别为两天、八天、两周、两个月和四个月。从BEKESSY等人(1976年)的模型得出的值显示,恶性疟原虫(每日发病率h:0.0119 - 0.0529;每日恢复率r:0.0043 - 0.0198)和三日疟原虫(h:0.0053 - 0.0103;r:0.0115 - 0.0428)的变化范围很大。对于卵形疟原虫,该模型仅适用于最大时间间隔为八天采集的样本(h:0.0048 - 0.0058;r:0.1400 - 0.1540)。虽然估计值之间的差异可能部分归因于疟疾传播的差异,但结果表明,只有短时间间隔的采样才能正确估计所研究人群中的发病率和恢复率。到目前为止,这个参数的重要性可能尚未得到充分考虑。

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