Taillan B, Garnier G, Ferrari E, Castanet J, Pesce A, Fuzibet J G, Dujardin P
Service de Médecine Interne I, Hôpital de Cimiez, Nice.
Rev Rhum Ed Fr. 1993 Mar;60(3):248-50.
The authors report a case of non-Hodgkin's malignant lymphoma which developed in a patient under low-dose methotrexate for rheumatoid arthritis. Although rheumatoid arthritis without immunosuppressive therapy may be associated with an increased incidence of malignant lymphoma, the immunosuppressive effects of methotrexate may further promote the development of malignant lymphoma.
作者报告了一例非霍奇金恶性淋巴瘤病例，该病例发生在一名接受低剂量甲氨蝶呤治疗类风湿性关节炎的患者身上。尽管未经免疫抑制治疗的类风湿性关节炎可能与恶性淋巴瘤发病率增加有关，但甲氨蝶呤的免疫抑制作用可能会进一步促进恶性淋巴瘤的发展。
