• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

合成免疫调节剂对造血CFU-S的辐射防护作用

[Radioprotective effect of synthetic immunomodulators on hemopoietic CFU-S].

作者信息

Sëmina O V, Semenets T N, Deĭgin V I, Korotkov A M, Poverennyĭ A M

出版信息

Radiats Biol Radioecol. 1993 Nov-Dec;33(6):808-11.

PMID:8293106
Abstract

The radiotherapeutic effect of thymogen (Glu-Trp) and thymohexin (Arg-Lys-Asp-Val-Tyr-Arg) synthetic peptide immunomodulators was investigated. Both thymogen and thymohexin were demonstrated to be able to reduce the damaging effect of ionizing radiation (1 Gy) on CFU-S by half. The treatment by these preparations after irradiation at dose of 4 Gy leads to more intensive restoration of CFU-S population as compared with control.

摘要

研究了胸腺生成素(Glu-Trp)和胸腺五肽(Arg-Lys-Asp-Val-Tyr-Arg)合成肽免疫调节剂的放射治疗效果。胸腺生成素和胸腺五肽均被证明能够将电离辐射(1 Gy)对脾集落形成单位(CFU-S)的损伤作用减半。与对照组相比,在4 Gy剂量照射后用这些制剂进行治疗可导致CFU-S群体更强烈地恢复。

相似文献

1
[Radioprotective effect of synthetic immunomodulators on hemopoietic CFU-S].合成免疫调节剂对造血CFU-S的辐射防护作用
Radiats Biol Radioecol. 1993 Nov-Dec;33(6):808-11.
2
[Adaptive response in vivo: reasons for increase of radioresistance in CFU-S].
Radiats Biol Radioecol. 1993 Nov-Dec;33(6):812-5.
3
[The replacement of accessory T-lymphocytes by synthetic peptides during the formation of splenic hematopoietic colonies].[脾脏造血集落形成过程中合成肽对辅助性T淋巴细胞的替代作用]
Biull Eksp Biol Med. 1993 Sep;116(9):298-9.
4
[The synthetic peptide D-(iEW) (thymodepressin) protects bone marrow CFU-S from ionizing radiation exposure].合成肽D-(iEW)(胸腺抑制素)可保护骨髓集落形成单位-S免受电离辐射暴露。
Radiats Biol Radioecol. 2000 May-Jun;40(3):315-8.
5
The effects of the EW dipeptide optical and chemical isomers on the CFU-S population in intact and irradiated mice.
Int Immunopharmacol. 2007 Mar;7(3):375-82. doi: 10.1016/j.intimp.2006.11.010. Epub 2006 Dec 20.
6
Restoration of femoral GM-CFC progenitors in sublethally irradiated mice of various ages treated with liposomal adamantylamide dipeptide.
Int Immunopharmacol. 2004 Aug;4(8):1099-106. doi: 10.1016/j.intimp.2004.05.005.
7
Combined radioprotective effect of Broncho-Vaxom and WR-2721 on hemopoiesis and circulating blood cells.支气管疫苗(Broncho-Vaxom)和WR-2721对造血及循环血细胞的联合辐射防护作用。
Neoplasma. 1995;42(1):25-30.
8
[Radiation protective effect of low molecular weight thymus preparations].[低分子量胸腺制剂的辐射防护作用]
Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):663-70.
9
Radioprotection of mice by the bacterial extract Broncho-Vaxom: haemopoietic stem cells and survival enhancement.细菌提取物Broncho-Vaxom对小鼠的辐射防护作用:造血干细胞与生存能力增强
Int J Radiat Biol. 1992 Apr;61(4):511-8. doi: 10.1080/09553009214551271.
10
Effect of the peptide of thymic origin (synthetic thymohexine-RKNVYR) on hemopoietic cell progenitors in intact and irradiated animals.
Immunol Lett. 1996 Jul;51(3):137-40. doi: 10.1016/0165-2478(96)02530-8.

引用本文的文献

1
Chemical Platform for the Preparation of Synthetic Orally Active Peptidomimetics with Hemoregulating Activity.用于制备具有血液调节活性的合成口服活性拟肽的化学平台。
ChemMedChem. 2016 Sep 20;11(18):1974-7. doi: 10.1002/cmdc.201600157. Epub 2016 Jul 26.