Mody I
Department of Anesthesiology/Pain Management, University of Texas Southwestern Medical Center, Dallas 75235-9068.
Brain Pathol. 1993 Oct;3(4):395-403. doi: 10.1111/j.1750-3639.1993.tb00767.x.
Kindling is an experimental model of epilepsy that involves activity-dependent changes in neuronal structure and function. During kindling, pathological changes may occur at several organizational levels of the nervous system, from alterations in gene-expression in individual neurons to the loss of specific neuronal populations and rearrangement of synaptic connectivity resulting from sustained stimulation of major excitatory pathways. This review summarizes recent developments in alterations at single neuronal and molecular levels that may be responsible for kindling epileptogenesis.
点燃效应是一种癫痫实验模型，涉及神经元结构和功能的活动依赖性变化。在点燃过程中，神经系统的几个组织层面可能会发生病理变化，从单个神经元基因表达的改变到特定神经元群体的丧失，以及主要兴奋性通路持续刺激导致的突触连接重排。本综述总结了可能与点燃性癫痫发生机制相关的单个神经元和分子水平变化的最新进展。
