McNamara J O
Department of Medicine (Neurology) and Neurobiology, Duke University Medical Center, North Carolina 27710, USA.
Psychiatry Clin Neurosci. 1995 Jun;49(3):S175-8. doi: 10.1111/j.1440-1819.1995.tb02167.x.
Kindling has become the most widely studied animal model of limbic epilepsy. Understanding the molecular basis of kindling development may provide novel therapeutic approaches to prevention of limbic epileptogenesis. I briefly describe the kindling model and outline the basis for my thinking that kindling represents a synaptic reorganization triggered by pathologic activity in the mature nervous system. The pathologic activity is postulated to evoke a cascade of gene expression driven, at least in part, by glutamate receptor activation. Evidence in support of this hypothesis is presented, as are future challenges that permit critical tests of these ideas.
点燃效应已成为研究最为广泛的边缘性癫痫动物模型。了解点燃效应发展的分子基础可能会为预防边缘性癫痫发生提供新的治疗方法。我简要描述一下点燃效应模型，并概述我认为点燃效应代表成熟神经系统中由病理活动触发的突触重组这一观点的依据。据推测，这种病理活动会引发一系列至少部分由谷氨酸受体激活驱动的基因表达。文中给出了支持这一假说的证据，以及能够对这些观点进行关键验证的未来挑战。
