Willmes K, Poeck K
Department of Neurology, RWTH Aachen, Germany.
Brain. 1993 Dec;116 ( Pt 6):1527-40. doi: 10.1093/brain/116.6.1527.
Modern views on the representation of function in the cortex make it difficult to maintain the notion that specific subtypes of aphasia are associated with specific centres within the language area. We have conducted a retrospective study on 221 aphasic patients with one contiguous vascular lesion in the territory of the middle cerebral artery. The localization of CT lesions was established within a standardized grid model. Aphasiological data were based on one or more examinations with the Aachen Aphasia Test. Both sets of data were processed in a data- and methodbase system. No unequivocal association between type of aphasia and localization of lesion was found. In a smaller study, participation of basal ganglia and in particular of the head of the caudate nucleus in lesions producing aphasia was not confirmed. Concepts of the localization of a lesion in aphasia must account for changes in patterns of aphasic symptoms in the presence of a stable lesion and for the impact of the neurological condition that has produced the lesion.
现代关于大脑皮层功能表征的观点，使得我们难以维持这样一种观念，即特定类型的失语症与语言区域内的特定中枢相关联。我们对221例大脑中动脉供血区域出现一处连续性血管病变的失语症患者进行了一项回顾性研究。CT病变的定位是在一个标准化网格模型内确定的。失语症学数据基于使用亚琛失语症测试进行的一次或多次检查。这两组数据都在一个数据和方法库系统中进行了处理。未发现失语症类型与病变定位之间存在明确关联。在一项规模较小的研究中，未证实基底神经节尤其是尾状核头部参与导致失语症的病变。失语症病变定位的概念必须考虑到在病变稳定的情况下失语症状模式的变化，以及导致病变的神经状况的影响。
