nm23 H-1 RNA水平在人胃癌组织中的表达。与淋巴结转移呈负相关。
Expression of nm23 H-1 RNA levels in human gastric cancer tissues. A negative correlation with nodal metastasis.
作者信息
Kodera Y, Isobe K, Yamauchi M, Kondoh K, Kimura N, Akiyama S, Itoh K, Nakashima I, Takagi H
机构信息
Department of Surgery II, Nagoya University School of Medicine, Japan.
出版信息
Cancer. 1994 Jan 15;73(2):259-65. doi: 10.1002/1097-0142(19940115)73:2<259::aid-cncr2820730205>3.0.co;2-v.
BACKGROUND
Gene expression of nm23 has been investigated in number of tumors, including breast cancer, colon cancer, malignant melanoma, and hepatocellular carcinoma. Its down-regulation has been shown to be associated with metastasis or disease progression in some of the tumors.
METHODS
nm23 H-1 mRNA levels were investigated in 31 surgically resected specimens of gastric cancer by Northern blot analysis, and association with clinical stages was determined.
RESULTS
There was no significant difference in nm23 expression between tumor and matching normal mucosa. There was a significant down-regulation of the nm23 gene in gastric cancer with serosal invasion (T3 and T4 by the TNM classification) and nodal metastasis (pN1 and pN2), although the association of the down-regulation with clinically manifest hepatic or peritoneal metastasis was not significant. The tumors with low nm23 expression were associated with a poor prognosis.
CONCLUSIONS
It was suggested that the down-regulation of nm23 gene might have a role in metastasis and invasion in gastric cancer, possibly leading to a poor prognosis.
背景
已在包括乳腺癌、结肠癌、恶性黑色素瘤和肝细胞癌在内的多种肿瘤中研究了nm23的基因表达。在某些肿瘤中，其下调已被证明与转移或疾病进展有关。
方法
通过Northern印迹分析研究了31例手术切除的胃癌标本中nm23 H-1 mRNA水平，并确定了其与临床分期的关系。
结果
肿瘤组织与配对的正常黏膜之间nm23表达无显著差异。在伴有浆膜侵犯（根据TNM分类为T3和T4）和淋巴结转移（pN1和pN2）的胃癌中，nm23基因有显著下调，尽管下调与临床明显的肝转移或腹膜转移之间的相关性不显著。nm23低表达的肿瘤与预后不良相关。
结论
提示nm23基因下调可能在胃癌转移和侵袭中起作用，可能导致预后不良。
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