Peel N, Eastell R
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield, Northern General Hospital, UK.
Baillieres Clin Rheumatol. 1993 Oct;7(3):479-98. doi: 10.1016/s0950-3579(05)80074-3.
Bone mass is the most important determinant of fracture risk. Current bone mass of an individual will be determined by the peak bone mass achieved in early adult life and the subsequent duration and rate of bone loss. In attempting to predict an individual's future risk of fracture it is therefore logical to attempt to assess both of these parameters. Serial measurements of bone mineral density and estimation of the rate of bone turnover may also be used to determine the response to treatment. In this chapter we review the currently available methods of measuring BMD and bone turnover, and discuss their place in the diagnosis and management of osteoporosis.
骨量是骨折风险的最重要决定因素。个体当前的骨量将由成年早期达到的峰值骨量以及随后的骨丢失持续时间和速率决定。因此，在试图预测个体未来的骨折风险时，尝试评估这两个参数是合乎逻辑的。骨密度的系列测量和骨转换率的估计也可用于确定治疗反应。在本章中，我们回顾了目前可用的测量骨密度和骨转换的方法，并讨论它们在骨质疏松症诊断和管理中的地位。
