关于对导致数量变异的加性和显性基因座有效数量估计的一则注释。
A note on the estimation of the effective number of additive and dominant loci contributing to quantitative variation.
作者信息
Ollivier L, Janss L L
机构信息
INRA-Station de Génétique quantitative et appliquée, Jouy-en-Josas, France.
出版信息
Genetics. 1993 Nov;135(3):907-9. doi: 10.1093/genetics/135.3.907.
A method of estimating the number of loci contributing to quantitative variation has been proposed by S. Wright in 1921. The method makes use of the means of inbred lines and the variances of their F1, F2 and backcrosses. The method has been extended to crosses between outbreeding populations by R. Lande in 1981. Additive gene action is one of the major assumptions required for obtaining valid estimates. It is shown here that this assumption may be relaxed. One can estimate both a total number of effective loci and a number of dominant loci (the latter only when the parents are inbred) by comparing the variances of the F1, F2 and backcrosses. Numerical illustrations are given, based on crossbreeding data.
1921年，S. 赖特提出了一种估计对数量变异有贡献的基因座数量的方法。该方法利用了近交系的均值及其F1、F2和回交的方差。1981年，R. 兰德将该方法扩展到远交群体之间的杂交。加性基因作用是获得有效估计所需的主要假设之一。本文表明该假设可以放宽。通过比较F1、F2和回交的方差，可以估计有效基因座的总数和显性基因座的数量（只有当亲本是近交系时才能估计后者）。基于杂交数据给出了数值示例。
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