Shiozawa H, Kagasaki T, Kinoshita T, Haruyama H, Domon H, Utsui Y, Kodama K, Takahashi S
Biomedical Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
J Antibiot (Tokyo). 1993 Dec;46(12):1834-42. doi: 10.7164/antibiotics.46.1834.
Thiomarinol, an antimicrobial antibiotic, was isolated from the culture broth of a marine bacterium, Alteromonas rava sp. nov. SANK 73390. Its structure was deduced as a hybrid composed of a pseudomonic acid analogue and holothin by NMR spectral analysis and chemical degradation. Antimicrobial activity against Gram-positive and Gram-negative bacteria of thiomarinol was stronger than both of pseudomonic acids and pyrrothine antibiotics.
硫代马瑞诺醇是一种抗菌抗生素，从海洋细菌新种Alteromonas rava SANK 73390的培养液中分离得到。通过核磁共振光谱分析和化学降解，推断其结构为由假单胞菌酸类似物和全硫素组成的杂合物。硫代马瑞诺醇对革兰氏阳性菌和革兰氏阴性菌的抗菌活性均强于假单胞菌酸和吡咯菌素类抗生素。
