具有抗流感病毒活性的3-表抑真菌素B类似物的合成。
Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.
作者信息
Nishimura Y, Umezawa Y, Kondo S, Takeuchi T, Mori K, Kijima-Suda I, Tomita K, Sugawara K, Nakamura K
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1993 Dec;46(12):1883-9. doi: 10.7164/antibiotics.46.1883.
PMID:8294247
Abstract
Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influenza virus infection in vitro.
摘要
通过对西他司丁B进行化学修饰，获得了西他司丁B的两种差向异构体，即3-表西他司丁B（3）和3,4-二表西他司丁B（4）。化合物3对流感病毒神经氨酸酶显示出显著的抑制活性，并且在体外对流感病毒感染有明显的抑制作用。
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