多系统器官衰竭：预后研究

Multiple system organ failure: a study of outcome.

作者信息

Phadke A Y, Jiandani P G

机构信息

Dept of Medicine, TNMC & BYL Nair Ch. Hospital, Bombay.

出版信息

J Assoc Physicians India. 1993 Aug;41(8):498-9.

PMID:8294351

Abstract

One hundred patients with Multiple System Organ Failure (MSOF) were studied. The precipitating factors were infections, poisoning, metabolic disorders, surgical disorders and cardiac arrest resulting in an overall mortality of 65%. Mean inpatient stay was 3.86 days, being significantly longer in patients who survived (6.25 days). Age, sex, addictions and premorbid health did not affect outcome. GIT (89%), CNS (81%) and Liver failure (62%) were seen most commonly. Highest mortalities were observed with RS (81.2%), CVS (80.37%) and CNS (76.5%). The mortality with 2,3,4,5,6 and 7 OSF was 8.3%, 18.7%, 70%, 92%, 100% and 100% respectively. The mortality was highest (50.76%) on the first day of MSOF and during the initial 48 hours of the total duration of disease. The method proposes an easily reproducible way to evaluate severity of illness and predicting outcome in acute MSOF.

摘要

对100例多系统器官衰竭（MSOF）患者进行了研究。诱发因素包括感染、中毒、代谢紊乱、外科疾病和心脏骤停，总死亡率为65%。平均住院时间为3.86天，存活患者的住院时间明显更长（6.25天）。年龄、性别、成瘾情况和病前健康状况不影响预后。最常见的是胃肠道（GIT）衰竭（89%）、中枢神经系统（CNS）衰竭（81%）和肝功能衰竭（62%）。呼吸系统（RS）衰竭（81.2%）、心血管系统（CVS）衰竭（80.37%）和中枢神经系统（CNS）衰竭（76.5%）的死亡率最高。2个、3个、4个、5个、6个和7个器官系统衰竭（OSF）的死亡率分别为8.3%、18.7%、70%、92%、100%和100%。在MSOF的第一天以及疾病总病程的最初48小时内死亡率最高（50.76%）。该方法提出了一种易于重复的方法来评估急性MSOF的疾病严重程度并预测预后。