Euvrard S, Kanitakis J, Pouteil-Noble C, Chardonnet Y, Touraine J L, Thivolet J
Department of Dermatology, Hôpital Edouard Herriot, Lyon, France.
J Am Acad Dermatol. 1994 Feb;30(2 Pt 2):300-3. doi: 10.1016/s0190-9622(94)70027-3.
Oral hairy leukoplakia (OHL) is a disorder of the tongue associated with Epstein-Barr virus (EBV). OHL is seen mainly in HIV infection but is also rarely seen in the course of iatrogenic immunosuppression, especially in kidney transplantation; OHL is even more rarely seen in immunocompetent hosts. Lesions that clinically and histologically mimicked OHL but were not associated with EBV were recently characterized as pseudo hairy leukoplakia. We present such a case that occurred in a renal allograft recipient; light and electron microscopy, immunohistochemistry, and in situ hybridization were used to examine the patient for the presence of EBV and human papillomavirus. Two independent treatments with topical retinoid and oral amoxicillin resulted in complete remission. Pseudo hairy leukoplakia may correspond, at least in some cases, to the conditions known as leukoedema and white sponge nevus; the distinction of these diseases from OHL is of importance because OHL is a hallmark of severe immunosuppression.
口腔毛状白斑（OHL）是一种与爱泼斯坦-巴尔病毒（EBV）相关的舌部疾病。OHL主要见于HIV感染，但在医源性免疫抑制过程中也很少见，尤其是在肾移植中；在免疫功能正常的宿主中更为罕见。临床上和组织学上模仿OHL但与EBV无关的病变最近被归类为假性毛状白斑。我们报告了一例发生在肾移植受者中的病例；使用光镜和电镜、免疫组化以及原位杂交技术检测患者是否存在EBV和人乳头瘤病毒。局部使用维甲酸和口服阿莫西林进行的两种独立治疗均导致完全缓解。假性毛状白斑至少在某些情况下可能与称为白色水肿和白色海绵状痣的疾病相对应；将这些疾病与OHL区分开来很重要，因为OHL是严重免疫抑制的标志。
