口腔病变作为艾滋病进展的重要标志。

Oral lesions as an important marker for HIV progression.

作者信息

Braz-Silva Paulo Henrique, Schussel Juliana Lucena, López Ortega Karen, Gallottini Marina

机构信息

Laboratory of Virology, Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil 2 Department of Stomatology, Division of General Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil. pbraz@usp. br.

出版信息

Dermatol Online J. 2017 Sep 15;23(9):13030/qt9t26m7n3.

PMID:29469724

Abstract

BACKGROUND

Oral hairy leukoplakia (OHL) is a benign lesion caused by Epstein-Barr virus (EBV) replication in the oral epithelium affecting the borders of the tongue. It is strongly associated with immunosuppression, especially in HIV+ adults but is uncommon in pediatric population. The aim of the study is to show the importance of the correct diagnosis of OHL and its influence on HIV treatment.We report two cases of HIV+ adolescent patients that presented with leukoplakic lesions on the border of the tongue, suggestive of OHL. OHL diagnosis was confirmed in only one case through EBV in situ hybridization. After confirmation of the diagnosis, the patient with OHL was referred to an infectious disease specialist with the decision to start antiretroviral therapy.

CONCLUSION

OHL definitive diagnosis can help clinical management of pediatric HIV+ patients.

摘要

背景

口腔毛状白斑（OHL）是由爱泼斯坦-巴尔病毒（EBV）在口腔上皮细胞中复制引起的良性病变，影响舌缘。它与免疫抑制密切相关，尤其是在HIV阳性的成年人中，但在儿科人群中并不常见。本研究的目的是展示正确诊断OHL的重要性及其对HIV治疗的影响。我们报告了两例HIV阳性青少年患者，他们在舌缘出现白斑病变，提示OHL。仅通过EBV原位杂交在一例中确诊为OHL。确诊后，OHL患者被转诊至传染病专家处，决定开始抗逆转录病毒治疗。