掌腱膜挛缩症患者真皮中肌成纤维细胞的存在。复发的一个可能来源。

The presence of myofibroblasts in the dermis of patients with Dupuytren's contracture. A possible source for recurrence.

作者信息

McCann B G, Logan A, Belcher H, Warn A, Warn R M

机构信息

Department of Histopathology, Norfolk and Norwich Hospital, Norwich, UK.

出版信息

J Hand Surg Br. 1993 Oct;18(5):656-61. doi: 10.1016/0266-7681(93)90029-f.

DOI:10.1016/0266-7681(93)90029-f

PMID:8294839

Abstract

Samples of skin and underlying cord obtained at dermofasciectomy for Dupuytren's contracture have been examined for the presence of smooth muscle alpha-actin (SM alpha-actin), a marker for myofibroblasts. 15 of the 20 samples stained positively for SM alpha-actin corresponding with areas of hypercellular Dupuytren's tissue. In 12 of these 15 samples SM alpha-actin-positive hypercellular Dupuytren's tissue extended into the dermis, in three cases reaching the epidermis. In eight samples, diffusely distributed cells positive for SM alpha-actin and resembling fibroblasts were seen in the dermis. These cells appeared to be separate from the Dupuytren's foci. The presence of hypercellular foci and isolated fibroblasts positive for SM alpha-actin within the dermis may explain the high recurrence rate of Dupuytren's disease after fasciectomy.

摘要

在因掌腱膜挛缩症进行筋膜切除术时获取的皮肤及深部条索样本，已针对肌成纤维细胞标志物平滑肌α-肌动蛋白（SMα-肌动蛋白）的存在情况进行了检查。20个样本中有15个对SMα-肌动蛋白呈阳性染色，与掌腱膜组织细胞增多区域相对应。在这15个样本中的12个里，SMα-肌动蛋白阳性的细胞增多的掌腱膜组织延伸至真皮层，有3例延伸至表皮层。在8个样本中，真皮层可见弥漫分布的、对SMα-肌动蛋白呈阳性且类似成纤维细胞样的细胞。这些细胞似乎与掌腱膜病灶是分开的。真皮层内存在细胞增多的病灶以及对SMα-肌动蛋白呈阳性的孤立成纤维细胞，这可能解释了筋膜切除术后掌腱膜疾病的高复发率。