Senda Y, Nishibu M, Kawai K, Mizukami Y, Hashimoto T
Central Clinical Laboratory, Kanazawa University School of Medicine.
Rinsho Byori. 1993 Dec;41(12):1338-42.
Serum level of type IV collagen was measured in 104 patients with various thyroid disease, and the relationship between its level and thyroid hormone level was examined. The type IV collagen was measured by the method of one step sandwich enzyme immunoassay (EIA) using two distinct monoclonal antibodies recognized triple-helical (TH) domain and 7-S domain, respectively. The serum level of type IV collagen was significantly high in the hyperthyroid patients compared with that in normal controls, and a significant positive correlation was found between its value and thyroid hormone levels (T3, T4, FT3, FT4). The elevated level of type IV collagen in hyperthyroid patients was decreased to normal level, when they became to euthyroid after antithyroid drug therapy for hyperthyroidism. The serum level of type IV collagen was in normal range in hypothyroid patients, but the value was increased to high normal range after T4-replacement therapy for hypothyroidism. This evidence indicates that the serum level of type IV collagen is closely related to thyroid hormone level in patient with various thyroid disease. Type IV collagen concentration might be one of the useful variables for evaluating the thyroid function, although its mechanism is not elucidated.
对104例患有各种甲状腺疾病的患者测定了血清IV型胶原水平，并检测了其水平与甲状腺激素水平之间的关系。IV型胶原采用一步夹心酶免疫测定法（EIA）进行检测，该方法使用两种分别识别三螺旋（TH）结构域和7-S结构域的不同单克隆抗体。与正常对照组相比，甲状腺功能亢进患者的血清IV型胶原水平显著升高，且其值与甲状腺激素水平（T3、T4、FT3、FT4）之间存在显著正相关。甲状腺功能亢进患者在接受抗甲状腺药物治疗后转为甲状腺功能正常时，升高的IV型胶原水平降至正常水平。甲状腺功能减退患者的血清IV型胶原水平在正常范围内，但在接受甲状腺激素替代治疗后，其值升高至正常高限范围。这一证据表明，各种甲状腺疾病患者的血清IV型胶原水平与甲状腺激素水平密切相关。尽管其机制尚不清楚，但IV型胶原浓度可能是评估甲状腺功能的有用指标之一。
