Ogura F, Morii H, Ohno M, Ueno T, Kitabatake S, Hamada N, Ito K
Horm Metab Res. 1980 Oct;12(10):537-40. doi: 10.1055/s-2007-999193.
The correlation between serum CoQ10 levels and serum thyroid hormones in thyroid disorders was investigated in the present studies. Serum CoQ10 was measured by high speed liquid chromatography utilizing ultraviolet detector. In normal controls, serum CoQ10 level of the male was higher than that of the female. Serum CoQ10 level in hyperthyroidism was significantly lower than that of euthyroid subjects. But in hypothyroidism, serum CoQ10 level did not show any significant difference from that of euthyroid subjects. Significant inverse correlations were demonstrated between log CoQ10 and log T3, log T4, log free T4, or log rT3. These data suggested abnormalities in the mitochondrial electron transport system in thyroid disorders.
本研究调查了甲状腺疾病患者血清辅酶Q10水平与血清甲状腺激素之间的相关性。采用高效液相色谱法结合紫外检测器测定血清辅酶Q10水平。在正常对照组中，男性血清辅酶Q10水平高于女性。甲状腺功能亢进患者的血清辅酶Q10水平显著低于甲状腺功能正常者。但甲状腺功能减退患者的血清辅酶Q10水平与甲状腺功能正常者相比无显著差异。log辅酶Q10与log T3、log T4、log游离T4或log反T3之间存在显著负相关。这些数据提示甲状腺疾病中线粒体电子传递系统存在异常。
