Sakurai M, Araie M, Oshika T, Mori M, Shoji N, Masuda K
Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
Jpn J Ophthalmol. 1993;37(3):252-8.
The mechanism underlying the intraocular pressure (IOP) lowering effect of a novel prostaglandin-related compound, (+)-isopropyl Z-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)-cyclopentyl]hept-5 -enoate (UF-021), and the influence of this new hypotensive agent on the permeability of the blood-aqueous barrier (BAB) were studied in albino rabbits. A single instillation of 0.06% UF-021 significantly lowered the IOP with a peak reduction of 5.2 mmHg without changing the aqueous flow rate. Uveoscleral outflow and outflow facility to general blood circulation were both increased. The BAB permeability evaluated with fluorescein isothiocyanate-labeled rabbit albumin (FITC-RA) showed approximately sixfold increase after a single instillation of 0.06% UF-021, which suggested a drug-induced compromise of the rabbit BAB.
研究了一种新型前列腺素相关化合物（+）-异丙基Z-7-[(1R,2R,3R,5S)-3,5-二羟基-2-(3-氧代癸基)-环戊基]庚-5-烯酸酯（UF-021）降低眼压（IOP）的潜在机制，以及这种新型降压药对血-房水屏障（BAB）通透性的影响。在白化兔中进行了研究。单次滴注0.06% UF-021可显著降低眼压，眼压峰值降低5.2 mmHg，而房水流量不变。葡萄膜巩膜外流和总体血液循环的流出率均增加。用异硫氰酸荧光素标记的兔白蛋白（FITC-RA）评估的血-房水屏障通透性在单次滴注0.06% UF-021后增加了约六倍，这表明药物引起了兔血-房水屏障的损害。
