Nöth U, Jäger L J, Lutz J, Haase A
Physikalisches Institut, Universität Würzburg, Germany.
Magn Reson Imaging. 1994;12(1):149-53. doi: 10.1016/0730-725x(94)92362-0.
The goal of this study was the development of a method that allows the acquisition of chemical shift selective 19F NMR images within a short measuring time. A train of small tip angle frequency selective pulses, each followed by a dephasing gradient of random strength, was used as a presaturation experiment for the suppression of the unwanted chemical shift components. Imaging was performed after presaturation using a SNAPSHOT-FLASH experiment. The acquisition time for a 64 x 128 image including the presaturation experiment amounted to only 470 ms. The sequence was applied in a 4.7 Tesla magnet to perform a longitudinal pharmacological study on the clearance of perfluoroocytlbromide (PFOB) in the liver and spleen of rats.
本研究的目标是开发一种方法，该方法能够在短测量时间内获取化学位移选择性19F NMR图像。一系列小翻转角频率选择性脉冲，每个脉冲之后跟随一个随机强度的去相位梯度，被用作预饱和实验以抑制不需要的化学位移成分。预饱和后使用快照FLASH实验进行成像。包括预饱和实验在内的64×128图像的采集时间仅为470毫秒。该序列应用于4.7特斯拉磁体，以对大鼠肝脏和脾脏中全氟辛基溴化物（PFOB）的清除进行纵向药理学研究。
