Börnert P, Norris D G, Koch H, Dreher W, Reichelt H, Leibfritz D
Universität Bremen, FRG.
Magn Reson Med. 1993 Feb;29(2):226-34. doi: 10.1002/mrm.1910290211.
The application of an ultra-fast low angle RARE technique for the 19F imaging of perfluorocarbons (PFCs) used as temporary blood substitutes is described. This sequence is attractive for fast 19F imaging studies that measure the biodistribution of PFCs in vivo, due to its high signal-to-noise ratio. Extensions of this technique for the chemical shift selective measurement of fluorine T1 values are presented. Using the linear dependence between the oxygen partial pressure (pO2) and the T1 relaxation rate of PFC resonances this technique makes possible the fast in vivo measurement of oxygen tension. Using the sequence in a diffusion sensitized form 19F measurements of the diffusion constants of PFCs are also presented. Phantom experiments to test the methods, and in vivo images obtained in rat studies are given and discussed.
本文描述了一种超快速低角度RARE技术在用作临时血液替代品的全氟碳化合物（PFC）的19F成像中的应用。该序列因其高信噪比，对于测量PFC在体内生物分布的快速19F成像研究具有吸引力。本文还介绍了该技术在氟T1值化学位移选择性测量方面的扩展。利用氧分压（pO2）与PFC共振的T1弛豫率之间的线性关系，该技术使得在体内快速测量氧张力成为可能。还介绍了使用扩散敏感形式的该序列对PFC扩散常数进行的19F测量。给出并讨论了用于测试这些方法的体模实验以及在大鼠研究中获得的体内图像。
