O'Neill G F
Department of Urology, Royal Newcastle Hospital, NSW.
Med J Aust. 1994 Feb 7;160(3):123-5.
To draw attention to a relationship between the taking of tiaprofenic acid (Surgam) and the development of severe non-bacterial cystitis.
Seven case reports.
Six women and one man aged between 62 and 83 years with severe chronic cystitis who were taking tiaprofenic acid regularly for osteoarthritis. Six of the seven had initially been diagnosed as having interstitial cystitis.
All patients had classic symptoms and minimal signs on physical examination of chronic cystitis but urinalyses showed sterile pyuria, microscopic haematuria and proteinuria. Their upper urinary tracts were normal. All had severe and diffuse mucosal inflammation noted on cystoscopy, which became more marked with distension. Histological examination of bladder biopsies showed severe acute and chronic inflammation. Symptoms were present for an average period of six months, resulting in great morbidity. All patients recovered completely after the withdrawal of tiaprofenic acid within four to eight weeks (average 5.7 weeks).
A strong case for a cause-and-effect relationship between tiaprofenic acid and non-bacterial cystitis has been presented and a clinical pattern of disease established. Awareness of this condition is needed to reduce its morbidity in the community and to remove the need for expensive investigations.
提醒人们注意服用噻洛芬酸（舒雅美）与严重非细菌性膀胱炎发生之间的关系。
七例病例报告。
6名女性和1名男性，年龄在62至83岁之间，患有严重慢性膀胱炎，因骨关节炎规律服用噻洛芬酸。七名患者中有六名最初被诊断为间质性膀胱炎。
所有患者均有慢性膀胱炎的典型症状且体格检查体征轻微，但尿液分析显示无菌性脓尿、镜下血尿和蛋白尿。他们的上尿路正常。膀胱镜检查显示所有患者均有严重弥漫性黏膜炎症，膀胱扩张时更为明显。膀胱活检组织学检查显示严重急慢性炎症。症状平均持续六个月，导致严重发病。所有患者在停用噻洛芬酸后四至八周内（平均5.7周）完全康复。
已有力证明噻洛芬酸与非细菌性膀胱炎之间存在因果关系，并确立了该病的临床模式。需要提高对这种疾病的认识，以降低其在社区中的发病率，并避免进行昂贵的检查。
