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对干粉吸入器比较性能标准的需求。

Need for a comparative performance standard for dry powder inhalers.

作者信息

Richards R, Saunders M

机构信息

Department of Respiratory Medicine, Llandough Hospital, Cardiff.

出版信息

Thorax. 1993 Nov;48(11):1186-7. doi: 10.1136/thx.48.11.1186.

DOI:10.1136/thx.48.11.1186
PMID:8296270
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC464925/
Abstract

The efficacy of dry powder inhalers is dependent on the inspiratory flow rate at which they are used. The resistance to airflow through five different dry powder inhaler devices was measured. The devices were shown to vary significantly, with the Turbohaler having the highest resistance. We suggest that the performance of dry powder inhalers should be assessed at comparable pressure drops producing clinically relevant inspiratory flow rates for each device.

摘要

干粉吸入器的疗效取决于其使用时的吸气流量。测量了五种不同干粉吸入器装置的气流阻力。结果显示这些装置差异显著,其中都保吸入器的阻力最高。我们建议,应在能为每种装置产生临床相关吸气流量的可比压力降下评估干粉吸入器的性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98bf/464925/bded98473d36/thorax00290-0096-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98bf/464925/bded98473d36/thorax00290-0096-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98bf/464925/bded98473d36/thorax00290-0096-a.jpg

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本文引用的文献

1
How to use a rotahaler.如何使用旋转式吸入器。
Arch Dis Child. 1986 Jan;61(1):11-4. doi: 10.1136/adc.61.1.11.
2
Inhalation rate of sodium cromoglycate determines plasma pharmacokinetics and protection against AMP-induced bronchoconstriction in asthma.色甘酸钠的吸入速率决定了其血浆药代动力学以及对哮喘中AMP诱导的支气管收缩的保护作用。
Eur Respir J. 1988 Dec;1(10):896-901.
3
Absorption and disposition kinetics of cromolyn sodium and the influence of inhalation technique.色甘酸钠的吸收与处置动力学及吸入技术的影响。
J Pharmacol Exp Ther. 1987 Jun;241(3):1028-32.
4
Peak inspiratory flow and inspiratory vital capacity of patients with asthma measured with and without a new dry-powder inhaler device (Turbuhaler).使用和不使用新型干粉吸入器装置(都保)测量的哮喘患者的吸气峰流速和吸气肺活量。
Eur Respir J. 1990 Oct;3(9):1037-41.
5
Influence of inspiratory flow rate upon the effect of a Turbuhaler.吸气流量对都保效果的影响。
Arch Dis Child. 1990 Mar;65(3):308-10. doi: 10.1136/adc.65.3.308.