Pedersen S
Arch Dis Child. 1986 Jan;61(1):11-4. doi: 10.1136/adc.61.1.11.
The bronchodilator response after five different modes of salbutamol inhalation by rotahaler was assessed in 15 asthmatic children in a double blind cross over study. Inspiratory flow rates lower than 50 litres/minute were associated with a significant reduction in response compared with flow rates higher than 60 litres/minute, but tilting the head back during inhalation and holding the breath for 10 seconds had no significant effect on bronchodilation. Peak inspiratory flow rates measured in 150 normal children and 13 asthmatic children with acute wheeze showed that many young children and many children with severe bronchoconstriction were unable to generate a sufficiently high inspiratory flow rate to obtain maximum benefit from rotahaler treatment. Children using a rotahaler should be taught to inhale as quickly as possible and not with a quiet deep breath as recommended in the instruction leaflets.
在一项双盲交叉研究中，对15名哮喘儿童通过旋转吸入器以五种不同方式吸入沙丁胺醇后的支气管扩张反应进行了评估。与高于60升/分钟的流速相比，低于50升/分钟的吸气流速与反应显著降低相关，但吸入时头向后仰并屏气10秒对支气管扩张无显著影响。对150名正常儿童和13名急性喘息的哮喘儿童测量的最大吸气流速表明，许多幼儿和许多严重支气管收缩的儿童无法产生足够高的吸气流速以从旋转吸入器治疗中获得最大益处。应教导使用旋转吸入器的儿童尽可能快速吸气，而不是像说明书中建议的那样安静地深呼吸。
