暴露于2,3,7,8-四氯二苯并对二恶英（TCDD）的雄性大鼠肾上腺中的脂质过氧化作用。

Lipid peroxidation in the adrenal glands of male rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

作者信息

Bestervelt L L, Piper D W, Pitt J A, Piper W N

机构信息

School of Public Health, Department of Pharmacology, University of Michigan, Ann Arbor 48109-2029.

出版信息

Toxicol Lett. 1994 Feb 1;70(2):139-45. doi: 10.1016/0378-4274(94)90157-0.

DOI:10.1016/0378-4274(94)90157-0

PMID:8296318

Abstract

This study was performed to determine whether TCDD (50 micrograms/kg; single oral dose) could induce adrenal microsomal lipid peroxidation, which might be correlated to decreased levels of cytochrome P-450 and 21-hydroxylase activity. The amount of malondialdehyde (MDA) formed was significantly higher than controls at days 1 through 5 following TCDD treatment. Microsomal cytochrome P-450 levels were depressed after lipid peroxidation at days 1, 3, and 5, and 21-hydroxylase activity decreased at day 5 after TCDD treatment. This study shows that TCDD stimulates adrenal microsomal lipid peroxidation which is associated with decreased cytochrome P-450 levels and 21-hydroxylase activity.

摘要

本研究旨在确定2,3,7,8-四氯二苯并-对-二恶英（TCDD，50微克/千克；单次口服剂量）是否能诱导肾上腺微粒体脂质过氧化，这可能与细胞色素P-450水平降低和21-羟化酶活性降低有关。在TCDD处理后的第1至5天，形成的丙二醛（MDA）量显著高于对照组。在第1、3和5天脂质过氧化后，微粒体细胞色素P-450水平降低，TCDD处理后第5天21-羟化酶活性下降。本研究表明，TCDD刺激肾上腺微粒体脂质过氧化，这与细胞色素P-450水平降低和21-羟化酶活性降低有关。