Hofmann M, Holzer A, Brockerhoff P, Rathgen G H
Frauenklinik, Johannes Gutenberg-Universität, Mainz.
Zentralbl Gynakol. 1993;115(11):495-9.
The objective of this study was to investigate the influence of high dose MPA on serum cholesterol, triglyceride, phospholipids as well as free fatty acids given to 17 patients with metastatic breast cancer. Before the therapy, the patients with cancer revealed higher level in serum cholesterol, triglyceride, phospholipids and C 12:0, C 18:0 as we found it in the control (13 patients without cancer). There was no significant change in lipid parameters by treatment with MPA whereas cortisol decreases and insulin increases under therapy. The results are discussed under biochemical aspects.
本研究的目的是调查给予17例转移性乳腺癌患者高剂量甲羟孕酮（MPA）对血清胆固醇、甘油三酯、磷脂以及游离脂肪酸的影响。在治疗前，癌症患者的血清胆固醇、甘油三酯、磷脂以及C12:0、C18:0水平高于我们在对照组（13例无癌症患者）中所发现的水平。用MPA治疗后脂质参数无显著变化，而治疗期间皮质醇水平下降，胰岛素水平上升。从生化方面对结果进行了讨论。
