[Relation of blood lipids and insulin to body fat content, body surface area and state of the subcutaneous fatty tissue in patients with breast and lung cancer].

The study was concerned with an evaluation of the results of examination of 203 breast and 158 lung cancer patients. Such constitutional features as excessive body weight, body fat level and body surface area as well as adipocyte diameter and FFA profile in subcutaneous fat tissue were to be in a greater correlation with lipid (triglyceride, cholesterol and non-esterified FFA) levels than the rates of lipolysis and liposynthesis in both study groups. There may be minor differences in the mechanisms of hypertriglyceridemia development in breast and lung cancer patients. The rise in blood triglyceride level was largely due to basal hyperinsulinemia and glucocorticoid hyperproduction in lung cancer patients, whereas, in breast cancer patients it was mostly determined by resistance to insulin and an increase in body surface area contributed by lean body mass.