儿童多发性硬化症的诊断

Diagnosing multiple sclerosis in childhood.

作者信息

van Lieshout H B, van Engelen B G, Sanders E A, Renier W O

机构信息

Institute of Neurology, University Hospital, Nijmegen, The Netherlands.

出版信息

Acta Neurol Scand. 1993 Nov;88(5):339-43. doi: 10.1111/j.1600-0404.1993.tb05354.x.

DOI:10.1111/j.1600-0404.1993.tb05354.x

PMID:8296532

Abstract

By presenting the cases of 3 children with laboratory supported definite multiple sclerosis [LSDMS] according to Poser's diagnostic criteria, we illustrate the difficulties of diagnosing MS in childhood. In search for appropriate diagnostic criteria for childhood MS, the literature on childhood MS is reviewed, and the 3 cases presented are compared with the 15 hitherto reported with the diagnosis LSDMS. Specific difficulties of diagnosing MS in childhood are discussed. They include history taking in children, the multiple differential diagnostic possibilities, and the various clinical presentations. Due to these specific difficulties in childhood MS, we conclude that a strict use of Poser's criteria is indispensable, especially in childhood MS.

摘要

通过呈现3例根据波泽诊断标准实验室确诊为明确的多发性硬化症（LSDMS）的儿童病例，我们阐述了儿童多发性硬化症诊断的困难之处。为寻找适用于儿童多发性硬化症的诊断标准，我们回顾了有关儿童多发性硬化症的文献，并将所呈现的3例病例与迄今报道的15例确诊为LSDMS的病例进行了比较。讨论了儿童多发性硬化症诊断中的具体困难。这些困难包括儿童病史采集、多种鉴别诊断可能性以及各种临床表现。由于儿童多发性硬化症存在这些特殊困难，我们得出结论，严格应用波泽标准是必不可少的，尤其是在儿童多发性硬化症的诊断中。