抗心磷脂抗体的存在可区分韦格纳肉芽肿和显微镜下多血管炎。

Presence of anticardiolipin antibodies discriminates between Wegener's granulomatosis and microscopic polyarteritis.

作者信息

Hergesell O, Egbring R, Andrassy K

机构信息

Departments of Medicine, University of Heidelberg, FRG.

出版信息

Adv Exp Med Biol. 1993;336:393-6. doi: 10.1007/978-1-4757-9182-2_68.

DOI:10.1007/978-1-4757-9182-2_68

PMID:8296643

Abstract

ANCA-tests are not always useful in evaluation of disease activity of patients with Wegener's granulomatosis (WG) and microscopic polyarteritis(MP). If ANCA-tests are failing in patients with Wegener's granulomatosis or microscopic polyarteritis, markers of activated coagulation are helpful in evaluation of disease activity. The measurement of anticardiolipin antibodies(ACA) may allow to discriminate between MP and WG, since ACA are only significantly elevated in patients with MP. Anticardiolipin antibodies (ACA) are acquired autoantibodies that are found in patients with a wide spectrum of clinical conditions, mainly systemic lupus erythematosus and related disorders. They are associated with increased thrombotic tendency. We investigated in patients with ANCA-positive vasculitis whether membrane phospholipids exposed in injured endothelial cells might stimulate the formation of ACA, thus contributing to the vascular thrombotic occlusion besides the activation of coagulation.

摘要

抗中性粒细胞胞浆抗体（ANCA）检测在评估韦格纳肉芽肿（WG）和显微镜下多血管炎（MP）患者的疾病活动度时并不总是有用。如果在韦格纳肉芽肿或显微镜下多血管炎患者中ANCA检测结果不理想，活化凝血标志物有助于评估疾病活动度。抗心磷脂抗体（ACA）的检测可能有助于区分MP和WG，因为ACA仅在MP患者中显著升高。抗心磷脂抗体（ACA）是获得性自身抗体，在多种临床疾病患者中均可发现，主要是系统性红斑狼疮及相关疾病。它们与血栓形成倾向增加有关。我们研究了ANCA阳性血管炎患者中，受损内皮细胞暴露的膜磷脂是否会刺激ACA的形成，从而除了激活凝血外还导致血管血栓性闭塞。