Kawamura H, Kimura M, Ichihara I
Department of Anatomy, Aichi Medical University, Japan.
Ann Anat. 1993 Dec;175(6):569-75. doi: 10.1016/s0940-9602(11)80251-7.
After long-term castration, rats were injected with cotton seed oil, testosterone- and estradiol-17 beta-cypionate (CS, TC and EC). The height of the epithelial cells of the ventral prostates from the castrated rats increased after TC and EC-injection. The secretory and basal cells formed two layers of epithelium, an inner layer near the lumen with pale nuclei and another layer with dark nuclei. These two layers could result from a reduction of secretory epithelial cells. Castration decreased the ratio of secretory cells to basal cells (S/B). TC-injection increased the ratio of S/B because of the secretory epithelial cell growth. Longer dark cells may be transient cells, appearing during the differentiation of basal cells into secretory epithelial cells. A sheet branching off from the basal lamina was observed. Androgen may stimulate the synthesis of the lamina, but whether it induces the synthesis or turnover of the basal lamina has not been established. EC increased the ventral prostatic weight and secretory epithelial cell height and induced the appearance of crystalline granules. Increase in S/B ratio may result from an increase in the secretory epithelial cells, but not from basal cell multiplication due to squamous metaplasia. The ratio is significantly correlated to the weight of the ventral prostate, but not to the secretory epithelial cell height. Its value could indicate the multiplication of secretory epithelial cells, differentiation of basal cells into epithelial cells, or both. It is probable that basal cells do not change in number, but control the size of the rat ventral prostate in response to the hormone level.
长期阉割后，给大鼠注射棉籽油、睾酮和17β-雌二醇环戊丙酸酯（CS、TC和EC）。注射TC和EC后，去势大鼠腹侧前列腺上皮细胞高度增加。分泌细胞和基底细胞形成两层上皮，靠近管腔的内层细胞核淡染，另一层细胞核深染。这两层可能是分泌上皮细胞减少所致。阉割降低了分泌细胞与基底细胞的比例（S/B）。注射TC后，由于分泌上皮细胞生长，S/B比例增加。较长的暗细胞可能是瞬态细胞，出现在基底细胞分化为分泌上皮细胞的过程中。观察到从基膜分支出来的一片结构。雄激素可能刺激基膜的合成，但它是否诱导基膜的合成或周转尚未确定。EC增加了腹侧前列腺重量和分泌上皮细胞高度，并诱导了结晶颗粒的出现。S/B比例增加可能是由于分泌上皮细胞增加，而不是由于鳞状化生导致基底细胞增殖。该比例与腹侧前列腺重量显著相关，但与分泌上皮细胞高度无关。其值可表明分泌上皮细胞的增殖、基底细胞向上皮细胞的分化，或两者兼而有之。基底细胞数量可能不变，但根据激素水平控制大鼠腹侧前列腺的大小。
