Fasan P O, Sulzer A J, Lobel H, Kagan I B
Afr J Med Med Sci. 1976 Jun;5(2):149-53.
Fluorescent and haemagglutinating antibody tests were performed on sera collected from fifty-two adult African students from a holoendemic region of malaria in Nigeria. Period of continuous residence in the U.S.A. among members of the group varied from 2 days to nearly 10 years. None has been diagnosed as having malaria since resident in the U.S.A. and none had taken any form of anti-malaria drug prophylaxis since departure from Nigeria. Both tests indicated that all the students had probably had a past infection with falciparium malaria. All gave a positive reaction to fluorescent antibody (FA) test and in 70% indirect haemagglutination (IHA) titres of 1:16 and above were demonstrated. Twenty-three per cent had FA titres of 1:4096. The malarial antibody titre levels decreased with increase in the interval since last exposure. Generally, the IHA titres were lower than the FA. No malaria parasite was seen in the blood of the students on the one occasion they were examined. The high titre values recorded in those who have been away from the endemic region for over three years suggests that falciparum parasites may persist in the body longer than the usually accepted limit of 3 years.
对从尼日利亚疟疾高度流行地区的52名成年非洲学生采集的血清进行了荧光抗体和血凝试验。该组成员在美国的连续居住时间从2天到近10年不等。自居住在美国以来，没有人被诊断出患有疟疾，自离开尼日利亚以来，也没有人服用过任何形式的抗疟疾药物预防。两项测试均表明，所有学生可能过去都感染过恶性疟原虫。所有人的荧光抗体（FA）测试均呈阳性反应，70%的人间接血凝（IHA）效价达到1:16及以上。23%的人FA效价为1:4096。疟原虫抗体效价水平随着自上次接触以来时间间隔的增加而降低。一般来说，IHA效价低于FA效价。在对学生进行检查的那一次，他们的血液中未发现疟原虫。那些离开流行地区超过三年的人所记录的高效价表明，恶性疟原虫可能在体内持续存在的时间比通常认为的3年期限更长。
