Eversole L R
Diagnostic Sciences, UCLA School of Dentistry, Los Angeles, California.
Eur J Cancer B Oral Oncol. 1993 Jul;29B(3):173-9. doi: 10.1016/0964-1955(93)90019-b.
Clear cell tumours, both benign and malignant, derive from a diverse group of epithelial cell types including renal epithelium, keratinising epithelium, cutaneous adnexa, salivary glands, odontogenic epithelium, melanocytes and even mesenchymally derived cells of adipose and tendon sheath. In the head and neck, clear cell tumours represent a singular challenge to the pathologist since the classic morphological features of malignant neoplasia exemplified by cytological atypia are frequently absent in malignant clear cell variants, thereby excluding reliance on this histopathological hallmark for the establishment of a diagnosis. The differential diagnosis of both benign and malignant clear cell tumours must take into account patterns of growth as well as the phenotype of accompanying cell populations when attempting to arrive at a definitive histological diagnosis. In this review article, the histopathology of head and neck tumours that harbour significant clear cell populations will be compared and contrasted.
透明细胞肿瘤，包括良性和恶性，源自多种上皮细胞类型，包括肾上皮、角化上皮、皮肤附属器、唾液腺、牙源性上皮、黑素细胞，甚至脂肪和腱鞘的间充质来源细胞。在头颈部，透明细胞肿瘤对病理学家来说是一个独特的挑战，因为恶性肿瘤的典型形态学特征，如细胞学异型性，在恶性透明细胞变体中常常不存在，因此不能依赖这种组织病理学特征来进行诊断。在试图做出明确的组织学诊断时，良性和恶性透明细胞肿瘤的鉴别诊断必须考虑生长模式以及伴随细胞群的表型。在这篇综述文章中，将对头颈部含有大量透明细胞群的肿瘤的组织病理学进行比较和对比。
