Roos P J, Glerum J H, Schroeders M J
Department of Pharmacy, Academic Medical Centre, Amsterdam, The Netherlands.
Pharm World Sci. 1993 Dec 17;15(6):269-75. doi: 10.1007/BF01871129.
The stability of sufentanil (5 micrograms/ml as citrate) in admixtures with glucose 5% or bupivacaine hydrochloride (2 mg/ml) in 100 ml polyvinyl chloride portable pump reservoirs was investigated during simulated infusion by an epidural catheter at 32 degrees C for 48 h and during storage at 4 degrees C and 32 degrees C for 30 days. During both experiments a small decrease (< 5%) in concentration of sufentanil and bupivacaine was observed. No loss of sufentanil or bupivacaine could be detected (in both experiments) in the portable pump reservoirs when stored at 4 degrees C for 30 days. A significant decrease of sufentanil was observed when stored at 32 degrees C after 30 days when diluted with glucose (9.2%) or in combination with bupivacaine (8.9%); also, the bupivacaine concentration decreased significantly (4.1%). It is concluded that sufentanil in portable pump reservoirs can be used under patient conditions at 32 degrees C for 7 days when diluted with glucose 5% or 3 days in combination with bupivacaine hydrochloride.
在32℃下通过硬膜外导管模拟输注48小时以及在4℃和32℃下储存30天的过程中，研究了舒芬太尼（5微克/毫升柠檬酸盐）与5%葡萄糖或盐酸布比卡因（2毫克/毫升）在100毫升聚氯乙烯便携式泵储液器中的混合液的稳定性。在两个实验中，均观察到舒芬太尼和布比卡因的浓度有小幅下降（<5%）。当在4℃下储存30天时，在便携式泵储液器中未检测到舒芬太尼或布比卡因的损失（在两个实验中）。当在32℃下储存30天后，用葡萄糖稀释（9.2%）或与布比卡因联合使用（8.9%）时，观察到舒芬太尼显著下降；同时，布比卡因浓度也显著下降（4.1%）。得出的结论是，便携式泵储液器中的舒芬太尼在患者条件下，当用5%葡萄糖稀释时，在32℃下可使用7天；与盐酸布比卡因联合使用时，在32℃下可使用3天。
