Roos P J, Glerum J H, Meilink J W, Zwang L
Department of Pharmacy, Academic Medical Centre, Amsterdam, The Netherlands.
Pharm World Sci. 1993 Jun 18;15(3):139-44. doi: 10.1007/BF02113943.
Sufentanil (5 micrograms/ml as citrate) was investigated for its stability when diluted with sodium chloride 0.9%, in 100 ml polyvinyl chloride portable pump reservoirs during administration under simulated epidural conditions at 32 degrees C for 48 h. Sufentanil was absorbed into the polyvinyl chloride, resulting in a reduction of 10.9% of the concentration after 48 h. The absorption of sufentanil (5 micrograms/ml as citrate), alone and in combination with bupivacaine hydrochloride (2 mg/ml), was investigated when diluted with sodium chloride 0.9% in combination with a citrate buffer (pH 4.6), in the same reservoirs under similar conditions. There was no loss of sufentanil after 48 h in both experiments. The effect of the pH on the absorption of sufentanil in polyvinyl chloride was investigated at different pH values. After storage for 21 days at 32 degrees C there was 5.1% loss of sufentanil at pH 4 and 80.6% loss at pH 6. The citrate buffer at the optimum pH (4.6) has a low, acceptable buffer capacity for epidural administration.
在32摄氏度的模拟硬膜外给药条件下，研究了枸橼酸舒芬太尼（5微克/毫升，以枸橼酸盐形式存在）在100毫升聚氯乙烯便携式泵储液器中用0.9%氯化钠稀释后的稳定性，持续48小时。舒芬太尼被聚氯乙烯吸收，48小时后浓度降低了10.9%。研究了枸橼酸舒芬太尼（5微克/毫升，以枸橼酸盐形式存在）单独以及与盐酸布比卡因（2毫克/毫升）联合使用时，在相同储液器中、相似条件下用0.9%氯化钠与枸橼酸盐缓冲液（pH 4.6）稀释后的吸收情况。在两个实验中，48小时后舒芬太尼均无损失。研究了不同pH值下pH对舒芬太尼在聚氯乙烯中吸收的影响。在32摄氏度下储存21天后，pH 4时舒芬太尼损失5.1%，pH 6时损失80.6%。最佳pH（4.6）的枸橼酸盐缓冲液对于硬膜外给药具有较低的、可接受的缓冲容量。
