局部和全身应用前列腺素E1与实验性皮瓣存活的研究。

A study of topical and systemic prostaglandin E1 and survival of experimental skin flaps.

作者信息

Sawada Y, Sugawara M, Hatayama I, Sone K

机构信息

Department of Plastic and Reconstructive Surgery, Hirosaki University School of Medicine, Japan.

出版信息

Br J Plast Surg. 1993 Dec;46(8):670-2. doi: 10.1016/0007-1226(93)90197-j.

DOI:10.1016/0007-1226(93)90197-j

PMID:8298779

Abstract

A study has been undertaken to investigate Prostaglandin E1 administration procedure for improving flap survival. Whether the drug was administered continuously or transcutaneously using a silicone gel drug delivery system; or was topically injected into the critical zone of the flap; or was intraperitoneally administered intermittently over an hour after surgery a statistically significant improvement of flap survival occurred (P < 0.01, Student's t-test). However, no improvement of flap survival was seen when the drug was administered only once intraperitoneally immediately after flap elevation, although administered doses of the drug in those rats was equal to the doses in the rats which received intermittent administration of the drug intraperitoneally over an hour after surgery.

摘要

已开展一项研究以调查前列腺素E1的给药程序对提高皮瓣存活率的作用。无论药物是通过硅胶凝胶给药系统持续给药还是经皮给药；或是局部注射到皮瓣的关键区域；还是在手术后一小时内间歇性腹腔内给药，皮瓣存活率均出现了统计学上的显著提高（P < 0.01，学生t检验）。然而，尽管皮瓣掀起后立即单次腹腔内给药的大鼠所接受的药物剂量与术后一小时内接受间歇性腹腔内给药的大鼠相同，但未观察到皮瓣存活率有所提高。