Harley A, Cooper J M, Schapira A H
Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.
Brain Res. 1993 Nov 12;627(2):349-53. doi: 10.1016/0006-8993(93)90341-j.
Inactivation of the mitochondrial respiratory chain in response to iron-induced oxidative stress has been studied in cultured cells. Iron loading resulted in malonaldehyde production, decreased levels of glutathione and reduced specific activities of both complexes I and IV of the respiratory chain. These results are discussed with respect to idiopathic Parkinson's disease, which is associated with increased iron levels and a specific decrease in complex I activity in the substantia nigra.
针对铁诱导的氧化应激反应，对培养细胞中线粒体呼吸链的失活进行了研究。铁负荷导致丙二醛生成、谷胱甘肽水平降低以及呼吸链复合体I和复合体IV的比活性降低。结合特发性帕金森病对这些结果进行了讨论，该病与铁水平升高及黑质中复合体I活性的特异性降低有关。
