[亮氨酸31，脯氨酸34]神经肽Y（NPY），而非NPY 20-36，产生与NPY相似的辨别性刺激效应并诱导食物摄入。

[Leu31,Pro34]neuropeptide Y (NPY), but not NPY 20-36, produces discriminative stimulus effects similar to NPY and induces food intake.

作者信息

Jewett D C, Cleary J, Schaal D W, Thompson T, Levine A S

机构信息

Department of Psychology, University of Minnesota, Minneapolis.

出版信息

Brain Res. 1993 Dec 17;631(1):129-32. doi: 10.1016/0006-8993(93)91197-z.

DOI:10.1016/0006-8993(93)91197-z

PMID:8298985

Abstract

Rats were trained to discriminate between an intracerebroventricular injection of 1.15 nmol of Neuropeptide Y (NPY) and a sham injection. Rats rapidly learned to press the appropriate lever during training. NPY's discriminative stimulus effects were compared to those of saline, and 1.15-3.45 nmol [Leu31,Pro34]NPY, a Y1 receptor agonist and NPY 20-36, Y2 receptor agonist. [Leu31,Pro34]NPY resulted in NPY-appropriate responding, whereas saline and NPY 20-36 did not. [Leu31,Pro34]NPY also increased food intake, but NPY 20-36 did not. This suggests that NPY's discriminative stimulus and orexigenic effects involve the Y1, but not the Y2, receptor.

摘要

训练大鼠区分脑室内注射1.15纳摩尔神经肽Y（NPY）和假注射。大鼠在训练过程中迅速学会按压相应的杠杆。将NPY的辨别性刺激效应与生理盐水以及1.15 - 3.45纳摩尔的[亮氨酸31，脯氨酸34]NPY（一种Y1受体激动剂）和NPY 20 - 36（Y2受体激动剂）的效应进行比较。[亮氨酸31，脯氨酸34]NPY导致出现与NPY相符的反应，而生理盐水和NPY 20 - 36则没有。[亮氨酸31，脯氨酸34]NPY还增加了食物摄入量，但NPY 20 - 36没有。这表明NPY的辨别性刺激和促食欲作用涉及Y1受体，而非Y2受体。