Nakajima M, Inui A, Asakawa A, Momose K, Ueno N, Teranishi A, Baba S, Kasuga M
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Peptides. 1998;19(2):359-63. doi: 10.1016/s0196-9781(97)00298-2.
In the present study, the effects of intracerebroventricular (ICV) NPY, [Leu31, Pro34]NPY and NPY13-36 have been evaluated with respect to anxiety in mice in the elevated plus maze. NPY had opposing effects on behavior, depending on the doses used. NPY decreased the normal preference for the closed arms of the maze at 0.7 nmol, indicating an anxiolytic effect; however, at 7 pmol NPY further increased the preference for the closed arm, indicating an anxiogenic effect. [Leu31, Pro34]NPY, a Y1-type receptor agonist, significantly reduced the preference for the closed arms at 70 pmol. NPY13-36, a Y2-type receptor agonist, significantly intensified the preference at 20 pmol. It has been demonstrated that NPY produces not only an anxiolytic effect via Y1-type receptors, but also an anxiogenic effect via Y2-type receptors. The time course of these NPY actions are quite different and the anxiogenic effect was observed only shortly after ICV NPY injection.
在本研究中，已在高架十字迷宫中评估了脑室内注射神经肽Y（NPY）、[亮氨酸31，脯氨酸34]NPY和NPY13 - 36对小鼠焦虑的影响。根据所使用的剂量不同，NPY对行为产生相反的作用。在剂量为0.7纳摩尔时，NPY降低了小鼠对迷宫封闭臂的正常偏好，表明具有抗焦虑作用；然而，在剂量为7皮摩尔时，NPY进一步增加了对封闭臂的偏好，表明具有致焦虑作用。[亮氨酸31，脯氨酸34]NPY，一种Y1型受体激动剂，在剂量为70皮摩尔时显著降低了对封闭臂的偏好。NPY13 - 36，一种Y2型受体激动剂，在剂量为20皮摩尔时显著增强了对封闭臂的偏好。已证明NPY不仅通过Y1型受体产生抗焦虑作用，还通过Y2型受体产生致焦虑作用。这些NPY作用的时间进程有很大差异，并且致焦虑作用仅在脑室内注射NPY后不久观察到。
