Abeler V M, Holm R, Nesland J M, Kjørstad K E
Department of Pathology, Norwegian Radium Hospital, Oslo.
Cancer. 1994 Feb 1;73(3):672-7. doi: 10.1002/1097-0142(19940201)73:3<672::aid-cncr2820730328>3.0.co;2-r.
Small cell carcinoma of the cervix is a rare and aggressive tumor. Most gynecologic oncology centers have little experience with this tumor, and only small series have been published.
Twenty-six patients with small cell carcinoma of the uterine cervix were treated at the Norwegian Radium Hospital. Clinical data, immunohistochemical characteristics, and infection with human papillomavirus were studied.
Twelve tumors were of oat cell type and 14 of intermediate cell type. Twelve tumors were associated with other forms of carcinoma: squamous cell carcinoma (6 tumors), adenocarcinoma (5 tumors), and adenocarcinoma in situ (1 tumor). Neuroendocrine differentiation was expressed in 79% of the tumors. Human papillomavirus (HPV)-18 was detected in 40% of the tumors and HPV-16 in 28%. Fifteen patients had Stage I disease, 7 had Stage II, 2 had Stage III, and 3 had Stage IV. Fourteen patients with Stage I and II disease underwent radical hysterectomy with pelvic lymph node dissection. In four, the operation was preceded by intracavitary radiation treatment. The patients with Stage II, III, and IV disease were treated with a combination of intracavitary radium, external beam radiation therapy, and chemotherapy. The 5-year survival rate was 14%. Four patients are alive, one with recurrent disease 50 months after diagnosis. Three patients free of disease have been followed up 26, 54, and 101 months, respectively.
Small cell carcinoma of the cervix is an aggressive tumor with a propensity for rapid recurrence; it is associated with high mortality.
宫颈小细胞癌是一种罕见且侵袭性强的肿瘤。大多数妇科肿瘤中心对这种肿瘤经验甚少，仅有少量病例系列报道发表。
挪威镭医院对26例宫颈小细胞癌患者进行了治疗。研究了临床数据、免疫组化特征及人乳头瘤病毒感染情况。
12例肿瘤为燕麦细胞型，14例为中间细胞型。12例肿瘤伴有其他类型的癌：鳞状细胞癌（6例）、腺癌（5例）和原位腺癌（1例）。79%的肿瘤有神经内分泌分化。40%的肿瘤检测到人乳头瘤病毒（HPV）-18，28%检测到HPV-16。15例患者为Ⅰ期疾病，7例为Ⅱ期，2例为Ⅲ期，3例为Ⅳ期。14例Ⅰ期和Ⅱ期疾病患者接受了根治性子宫切除术及盆腔淋巴结清扫术。其中4例在手术前进行了腔内放射治疗。Ⅱ期、Ⅲ期和Ⅳ期疾病患者接受了腔内镭疗、体外照射放疗及化疗联合治疗。5年生存率为14%。4例患者存活，1例在诊断后50个月出现复发。3例无病患者分别随访了26、54和101个月。
宫颈小细胞癌是一种侵袭性肿瘤，易于快速复发，死亡率高。
