Walker A N, Mills S E, Taylor P T
Department of Pathology, Mercer University School of Medicine, Macon, Georgia 31207.
Int J Gynecol Pathol. 1988;7(1):64-74.
Fourteen primary cervical neoplasms with light microscopic features of neuroendocrine carcinoma were studied. Two were of intermediate cell type (IC), resembling the pulmonary atypical carcinoid; seven were small cell type (SC), analogous to pulmonary oat cell carcinoma; two were SC with foci of IC; three were SC with foci of squamous or adenocarcinoma. Four patients were Stage I, five were Stage II, two were Stage III, and three were Stage IV. One patient (Stage I) underwent hysterectomy and has completed radiation therapy. Two patients underwent radical hysterectomy and chemotherapy. One received radiation and chemotherapy; one received only chemotherapy; nine received radical radiation therapy. One patient (Stage I) is alive and well 10.5 years later; one (Stage II) died of other causes 24 months after diagnosis. One other is alive with the disease 12 months postdiagnosis. Eleven died secondary to tumor, four to 33 months (mean 14, median 12.5 months) after diagnosis. There was no significant difference in survival between IC and SC types, either mixed or pure. Cervical neuroendocrine carcinomas are biologically aggressive neoplasms, regardless of histologic type.
对14例具有神经内分泌癌光镜特征的原发性宫颈肿瘤进行了研究。其中2例为中间细胞型（IC），类似于肺非典型类癌；7例为小细胞型（SC），类似于肺燕麦细胞癌；2例为伴有IC灶的SC；3例为伴有鳞状或腺癌灶的SC。4例患者为Ⅰ期，5例为Ⅱ期，2例为Ⅲ期，3例为Ⅳ期。1例患者（Ⅰ期）接受了子宫切除术并完成了放射治疗。2例患者接受了根治性子宫切除术和化疗。1例接受了放疗和化疗；1例仅接受了化疗；9例接受了根治性放射治疗。1例患者（Ⅰ期）在10.5年后存活且状况良好；1例（Ⅱ期）在诊断后24个月死于其他原因。另1例在诊断后12个月仍患有该疾病存活。11例死于肿瘤，诊断后4至33个月（平均14个月，中位数12.5个月）。IC型和SC型（混合或纯合）之间的生存率无显著差异。宫颈神经内分泌癌无论组织学类型如何，在生物学上都是侵袭性肿瘤。
