Heinemann L, Richter B
Department of Nutrition and Metabolic Diseases (WHO Collaborating Center for Diabetes), Heinrich-Heine-University of Düsseldorf, Germany.
Diabetes Care. 1993 Dec;16 Suppl 3:90-100. doi: 10.2337/diacare.16.3.90.
Nowadays, human insulin is used daily by millions of diabetic patients. The biological effect of human insulin is comparable to that of porcine insulin. However, after subcutaneous injection, pharmacological and clinical studies showed pharmacokinetic and pharmacodynamic differences between human and animal insulins. Human insulin tends to have faster absorption and shorter duration of action compared with animal insulin. These differences are more pronounced and can be of clinical relevance with intermediate- and long-acting insulin preparations. Optimal metabolic control can be achieved with either human or highly purified animal insulin preparations, provided appropriate insulin replacement strategies are used.
如今，数百万糖尿病患者每天都在使用人胰岛素。人胰岛素的生物学效应与猪胰岛素相当。然而，皮下注射后，药理和临床研究表明，人胰岛素和动物胰岛素在药代动力学和药效学方面存在差异。与人胰岛素相比，动物胰岛素的吸收往往更快，作用持续时间更短。这些差异在中效和长效胰岛素制剂中更为明显，可能具有临床相关性。只要采用适当的胰岛素替代策略，使用人胰岛素制剂或高纯度动物胰岛素制剂均可实现最佳的代谢控制。
