Behar E, Carp H, Livneh A, Gazit E
Tissue Typing Laboratory, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Gynecol Obstet Invest. 1993;36(4):202-7. doi: 10.1159/000292630.
In order to investigate the possible role of suppressor cells in paternal leukocyte immunization to prevent recurrent miscarriages, peripheral blood lymphocytes from habitually aborting women before and after immunization were assessed. Immunization-induced suppressor activity as shown by (1) rise in CD8-positive cells and a decline in the CD4/CD8 ratio, (2) failure of cyclosporine A to inhibit the proliferation of phytohemagglutinin- and alloantigen-stimulated cells and (3) unresponsiveness to the immunizing spouses' antigen. These findings resembled those in normal pregnant women. Hence, paternal leukocyte immunization may induce specific and nonspecific T cell suppression which may induce the immune tolerance necessary to maintain pregnancy.
为了研究抑制性细胞在父本白细胞免疫预防复发性流产中可能发挥的作用，对习惯性流产妇女免疫前后的外周血淋巴细胞进行了评估。免疫诱导的抑制活性表现为：（1）CD8阳性细胞增多，CD4/CD8比值下降；（2）环孢素A不能抑制植物血凝素和同种抗原刺激的细胞增殖；（3）对免疫配偶的抗原无反应。这些发现与正常孕妇的情况相似。因此，父本白细胞免疫可能诱导特异性和非特异性T细胞抑制，这可能诱导维持妊娠所需的免疫耐受。
