Carp H J, Ben-Shlomo I, Toder V, Nebel L, Mashiach S
Department of Obstetrics and Gynaecology, Sheba Medical Center, Tel Hashomer, Israel.
Gynecol Obstet Invest. 1993;36(4):198-201. doi: 10.1159/000292629.
The risk of congenital malformations as assessed in infants born to women who underwent immunotherapy for habitual abortion. One hundred and eighty women were immunized with paternal mononuclear cells and 85 were not. Of 135 pregnancies in immunized patients, 27 (20%) were miscarriages, and 4 of the remaining 108 had congenital malformations. Two (encephalocele and common AV canal) were diagnosed in the 20th and 21st week of gestation. A case of esophageal atresia and Fallot's tetralogy were diagnosed at birth. Of 65 pregnancies in the non-immunized group 38 (58.5%) were miscarriages, and of the remaining 27, 1 case of Down's syndrome occurred. In a subgroup of 7 habitually aborting couples with parental balanced chromosomal anomalies, the balanced translocation was transferred to the infant in 1 case. No other congenital anomalies were found in either group. Consequently, these anomalies are probably not the result of abnormal pregnancies retained as a result of immunization.
对接受习惯性流产免疫治疗的女性所生婴儿的先天性畸形风险进行评估。180名女性接受了父方单核细胞免疫，85名未接受。在接受免疫治疗的患者的135次妊娠中，27例（20%）流产，其余108例中有4例出现先天性畸形。2例（脑膨出和共同房室通道）在妊娠第20周和第21周被诊断出来。1例食管闭锁和法洛四联症在出生时被诊断出来。在未接受免疫治疗的组的65次妊娠中，38例（58.5%）流产，其余27例中有1例发生唐氏综合征。在7对习惯性流产且父母染色体平衡异常的夫妇亚组中，1例平衡易位遗传给了婴儿。两组均未发现其他先天性异常。因此，这些异常可能不是免疫治疗导致的异常妊娠留存的结果。
