爱丁堡和纽卡斯尔的淋球菌感染：与临床特征及性取向相关的血清型流行情况

Gonococcal infection in Edinburgh and Newcastle: serovar prevalence in relation to clinical features and sexual orientation.

作者信息

Ross J D, Wardropper A, Sprott M, Moyes A, Young H

机构信息

Department of Genitourinary Medicine, Edinburgh Royal Infirmary, UK.

出版信息

Genitourin Med. 1994 Feb;70(1):35-9. doi: 10.1136/sti.70.1.35.

DOI:10.1136/sti.70.1.35

PMID:8300098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1195177/

Abstract

AIMS

The variable distribution of gonococcal serovars in different areas is well recognised but the factors that are important determinants of serovar prevalence are less clear. The aim of this study was to identify relevant clinical variables by comparing serovar prevalence in two cities over the same time period.

METHODS

A prospective analysis of serovar prevalence was made between January and December 1992 in Edinburgh and Newcastle with respect to age, sex, sexual orientation, antibiotic sensitivity and presence of symptoms.

RESULTS

224 infective episodes of gonorrhoea were studied. The serovar distribution varied between the two cities with serovar 1B-1 being more common in Edinburgh (20/91 cf. 4/133, p < 0.01) and serovar 1B-6 more common in Newcastle (26/133 cf. 2/91, p < 0.01). Serovar 1A-2 was associated with heterosexual infection (35/114 in heterosexuals cf. 0/85 in homosexuals, p < 0.01) and was more sensitive to penicillin than average (39/39 1A-2 strains highly penicillin sensitive cf. 98/184 for all other strains, p < 0.01) whilst 1B-6 was mostly acquired through homosexual contact (22/26 cf. 63/142 for all other strains, p < 0.01) and tended to show reduced penicillin susceptibility (13/28 1B-6 strains less penicillin sensitive cf. 45/195 for all other strains, p < 0.01). Infection with serovar 1A-2 was significantly less often symptomatic in heterosexuals than average (15/33 asymptomatic 1A-2 infections cf. 17/59 for all other serovars, p = 0.015). Subgroup analysis of male heterosexual infections confirms an association between asymptomatic infection and serovar 1A-2 (2/14 asymptomatic 1A-2 infections cf. 1/72 for all other serovars, p = 0.02). The distribution of infections over the year differed between the cities.

CONCLUSIONS

A variety of factors including penicillin sensitivity and virulence may be important in determining the prevalence of gonococcal serovars within a given area.

摘要

目的

淋病菌血清型在不同地区的分布差异已得到充分认识，但血清型流行率的重要决定因素尚不清楚。本研究旨在通过比较同一时期两个城市的血清型流行率来确定相关临床变量。

方法

1992年1月至12月，对爱丁堡和纽卡斯尔的淋病血清型流行率进行前瞻性分析，涉及年龄、性别、性取向、抗生素敏感性和症状表现。

结果

共研究了224例淋病感染病例。两个城市的血清型分布有所不同，血清型1B - 1在爱丁堡更为常见（20/91对比4/133，p < 0.01），血清型1B - 6在纽卡斯尔更为常见（26/133对比2/91，p < 0.01）。血清型1A - 2与异性传播感染相关（异性感染者中35/114，同性恋者中0/85，p < 0.01），且对青霉素的敏感性高于平均水平（39/39株1A - 2菌株对青霉素高度敏感，对比所有其他菌株98/184，p < 0.01）；而1B - 6大多通过同性接触感染（22/26对比所有其他菌株63/142，p < 0.01），且对青霉素的敏感性往往降低（13/28株1B - 6菌株对青霉素敏感性较低，对比所有其他菌株45/195，p < 0.01）。异性感染者中，血清型1A - 2感染出现症状的频率显著低于平均水平（15/33例无症状1A - 2感染，对比所有其他血清型17/59，p = 0.015）。男性异性传播感染的亚组分析证实无症状感染与血清型1A - 2之间存在关联（2/14例无症状1A - 2感染，对比所有其他血清型1/72，p = 0.02）。两个城市全年的感染分布情况有所不同。