一例可能为组织侵袭性淋病的病例聚集。
A case cluster of possible tissue invasive gonorrhoea.
作者信息
Brook M G, Clark S, Stirland A, Kelsey M C, Paice E W, Kell P D, Atia W A
机构信息
Archway Sexual Health Clinic, Camden and Islington Community Health Services NHS Trust, UK.
出版信息
Genitourin Med. 1995 Apr;71(2):126-8. doi: 10.1136/sti.71.2.126.
OBJECTIVE
To describe a cluster of patients presenting with severe symptoms and infected with an unusual strain of Neisseria gonorrhoeae.
SETTING
A north London Department of Sexual Health.
PATIENTS
Five patients were linked by reported sexual contact or other epidemiological evidence as part of a cluster of gonococcal infection. Cultured N gonorrhoea were subtyped by serological (serovar) and cultural (auxotype) methods and antibiotic sensitivities measured by minimum inhibitory concentration (MIC).
RESULTS
Four of the patients had severe gonorrhoea-related systemic or extragenital symptoms: disseminated gonococcal infection with oligoarthritis (1 patient), acute pelvic inflammatory disease (1 patient, who was also chlamydia positive) and tender inguinal adenopathy (2 patients). The fifth patient was asymptomatic. N gonorrhoeae was isolated in four of the patients. All four organisms had identical MICs. Three of the organisms were subtyped and found to be the same rare strain (serovar 1A1, auxotype NR).
CONCLUSION
This case cluster provides evidence for strain-related virulence in an uncommon gonococcal subtype.
目的
描述一群出现严重症状且感染了一种不寻常淋病奈瑟菌菌株的患者。
背景
伦敦北部性健康部门。
患者
五名患者通过报告的性接触或其他流行病学证据相互关联，属于一组淋球菌感染病例。培养的淋病奈瑟菌通过血清学（血清型）和培养（辅助型）方法进行亚型分类，并通过最低抑菌浓度（MIC）测定抗生素敏感性。
结果
四名患者出现与淋病相关的严重全身或生殖器外症状：播散性淋球菌感染伴寡关节炎（1例患者）、急性盆腔炎（1例患者，该患者衣原体检测也呈阳性）和腹股沟淋巴结压痛（2例患者）。第五名患者无症状。四名患者中分离出淋病奈瑟菌。所有四种菌株的MIC相同。其中三种菌株进行了亚型分类，发现是同一罕见菌株（血清型1A1，辅助型NR）。
结论
该病例组为一种不常见淋病奈瑟菌亚型中与菌株相关的毒力提供了证据。
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