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In vitro effects of Fasciola hepatica on the main functions of polymorphonuclear leukocytes: chemotaxis and free radical generation induced by phagocytosis.

作者信息

Baéza E, Poitou I, Boulard C

机构信息

Institut National de la Recherche Agronomique, INRA, Nouzilly, France.

出版信息

Int J Parasitol. 1993 Dec;23(8):1077-81. doi: 10.1016/0020-7519(93)90130-q.

DOI:10.1016/0020-7519(93)90130-q
PMID:8300302
Abstract

The effects of adult fluke excretions-secretions (ES) on two major functions of circulating bovine polymorphonuclear (PMN) cells were investigated. Under agarose, PMN chemotaxis was not affected by the ES. ES preincubated with PMN for 15, 30 or 60 min at 37 degrees C, before a chemoluminescence assay, inhibited phagocytosis and/or free radical generation in a dose and time dependent manner.

摘要

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Fasciola hepatica soluble antigens (FhAg) induce ovine PMN innate immune reactions and NET formation in vitro and in vivo.肝片形吸虫可溶性抗原（FhAg）在体外和体内诱导绵羊PMN 固有免疫反应和 NET 形成。
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