Lawman M J, Gifford G, Gyongyossy-Issa M, Dragan R, Heise J, Babiuk L A
Veterinary Infectious Disease Organization, Saskatoon, Saskatchewan, Canada.
Antiviral Res. 1987 Dec;8(5-6):225-37. doi: 10.1016/s0166-3542(87)80001-3.
Following infection of cattle with bovine herpes virus-1 there is a state of generalized immunosuppression involving various leukocytes including polymorphonuclear (PMN) leukocytes. Since the PMN is considered to be pivotal in recovery from secondary bacterial infections during bovine respiratory disease, investigations were initiated to determine PMN activity in this disease and whether interferon could modulate PMN activity. In this study, the in vivo administration of recombinant interferon alpha-I1 was shown to increase PMN functions as measured by migration/chemotaxis and generation of reactive oxygen species. This augmented activity of PMN appeared to correlate with the reduction of overall clinical disease, that is, number of sick days, lung lesions and weight loss. In the study administration of interferon by the intranasal or intramuscular route were as effective in stimulating PMN function. Based on these studies it was concluded that the reason for improved performance of calves treated with interferon would be due to its immunomodulatory effects on leukocytes. Although interferon did not alter the initial suppression of PMN functions, these functions returned to normal and exceeded normal activities by 7-9 days post-infection, the time when maximal bacterial activity normally is present.
牛感染牛疱疹病毒1型后，会出现一种全身性免疫抑制状态，涉及包括多形核（PMN）白细胞在内的各种白细胞。由于PMN被认为在牛呼吸道疾病继发细菌感染的恢复过程中起关键作用，因此开展了相关研究，以确定该疾病中PMN的活性，以及干扰素是否能调节PMN的活性。在本研究中，通过迁移/趋化作用和活性氧生成来衡量，结果显示体内给予重组干扰素α-I1可增强PMN功能。PMN活性的增强似乎与总体临床疾病的减轻相关，即患病天数、肺部病变和体重减轻情况。在该研究中，经鼻内或肌肉内途径给予干扰素在刺激PMN功能方面同样有效。基于这些研究得出的结论是，用干扰素治疗的犊牛表现改善的原因是其对白细胞的免疫调节作用。虽然干扰素并未改变PMN功能的初始抑制状态，但这些功能在感染后7 - 9天恢复正常并超过正常活性，而这正是通常存在最大细菌活性的时间。
